The uncontrolled shaking of the thumb is either a physiological reaction or a pathological cause, which should be promptly identified and treated symptomatically. The common causes of uncontrolled thumb trembling are as follows: First, it is due to mental factors such as nervousness, excitement and fright, which should be relieved by the patient’s own mediation to eliminate fear and tension. Second, the uncontrolled shaking of the thumb may be due to alcohol poisoning, or due to drug poisoning caused by nerve damage later, this situation should be promptly examined in the hospital and give symptomatic treatment, such as taking b vitamins or taking nerve nutrition drugs, can play a good role. Third, the uncontrolled shaking of the thumb may be caused by a disease, such as Parkinson’s syndrome, idiopathic tremor and other diseases, there will be uncontrolled shaking of the thumb, especially Parkinson’s syndrome is often in the quiet time shaking is more obvious, this situation should be promptly examined and symptomatic treatment.