High immunoglobulin E is associated with the pathogenesis of lupus erythematosus and disease activity. 1. Related to pathogenesis. Lupus erythematosus is an autoimmune disease, immunoglobulin E is involved in the role of autoimmune response to damage in lupus erythematosus patients, high levels of immunoglobulin E antibodies in active lupus erythematosus patients can make histamine, leukotriene, kinin and many other biologically active substances release. The high level of immunoglobulin E antibodies in patients with active lupus erythematosus can increase the release of histamine, leukotrienes, kinins and other biologically active substances. It causes inflammatory damage to tissues and organs. 2. Related to the activity of the disease. The level of immunoglobulin E in lupus erythematosus patients is higher than that in the inactive period, and the level of immunoglobulin E in lupus erythematosus patients is higher than that in healthy people. In addition, when immunoglobulin E is high, it is also necessary to be alert to whether it is combined with other diseases such as allergic rhinitis. It is recommended that lupus patients go to the rheumatology department of a regular hospital and receive standardized treatment under the guidance of a doctor.