The most common cause of high bilirubin hematology is caused by hemolysis, hemolytic anemia should be excluded first, common tests include blood routine, coagulation function, hepatitis serum virology, biochemical function test, autoantibody test, Coombs test, bone puncture and so on. 1. Blood routine: patients with hyperbilirubinemia caused by hemolysis will have anemia, which can tell whether the patient has hemolytic jaundice. 2. Coagulation function: some patients may have decreased coagulation function, through this test, we can know the severity of coagulation dysfunction. 3. Hepatitis serovirology: most of the hepatitis can lead to high bilirubin, which can help to clarify the cause of the disease. 4. Biochemical function test: total bilirubin includes direct bilirubin and indirect bilirubin. Depending on the etiology of hyperbilirubinemia, direct bilirubin and indirect bilirubin may be elevated to different degrees. Hyperbilirubinemia caused by liver disease may result in elevated aminotransferases and decreased liver function. 5. Autoantibody test: to rule out the presence of autoimmune hemolytic anemia and to clarify the etiology. 6. Coombs test: i.e. human globulin test, which is used to detect warm reactive antibodies in the blood, and is also an important indicator for the diagnosis of autoimmune hemolytic anemia. 7. Bone Marrow Puncture: Bone marrow aspiration should be performed under the guidance of a doctor when the cause of elevated bilirubin is not clear from the above tests. Patients with high bilirubin should follow the doctor’s instructions and actively cooperate with the doctor to avoid delaying the condition.