The N-terminal brain natriuretic peptide precursor, usually referred to as NT-proBNP, is an important indicator of heart failure and is seen in conditions such as chronic obstructive pulmonary disease and renal insufficiency. Brain natriuretic peptide (BNP) is a chemical secreted primarily by ventricular myocytes that negatively feedback regulates ventricular filling pressures in response to changes in ventricular wall tone.NT-proBNP is a substance produced by iso-molecular weights of BNP, which is an important diagnostic and prognostic indicator of heart failure.Elevated NT-proBNP can be seen in patients with heart failure. Elevated NT-proBNP is not a specific indicator of heart failure. Other conditions such as tachycardia, myocardial ischemia, left ventricular hypertrophy, hypoxia such as chronic obstructive pulmonary disease, renal insufficiency, pulmonary artery embolism, and cirrhosis of the liver may also cause elevated NT-proBNP. Therefore, if NT-proBNP is found to be elevated, it is recommended to go to the hospital to improve the examination, clarify the diagnosis, and then choose the appropriate intervention.