A cerebrospinal fluid test is needed to rule out the possibility of neurosyphilis if the titer is still 1:8 after more than 10 years of syphilis treatment. Syphilis titer at 1:1 is normal, titer 1:8 indicates the existence of syphilis infection, syphilis activity is relatively strong, also has a strong infectious. If the syphilis through the regular reasonable standardized treatment, the titer will usually gradually reduce until turn negative, if syphilis treatment for more than ten years titer did not decline, turn negative, may be not standardized treatment lead to syphilis treatment is not complete, syphilis continues to develop into neurosyphilis. In order to determine whether neurosyphilis has occurred, further cerebrospinal fluid examination is needed to rule out neurosyphilis. If diagnosed with neurosyphilis, penicillin treatment is preferred, and according to the condition, anti-epileptic drugs and painkillers are chosen as appropriate. If you have been treated for syphilis for more than ten years and the titer is still 1:8, you need to go to the hospital as soon as possible to get a clear diagnosis, and actively use medication under the guidance of the doctor.