Gastric cramps mainly manifest as epigastric pain and vomiting, and therefore usually require antispasmodic and antiemetic treatment. The antispasmodic treatment is often carried out clinically with drugs such as tincture of belladonna, atropine and pethidine hydrochloride, which can be supplemented with drugs such as omeprazole to inhibit gastric acid secretion and relieve pain: 1. Tincture of belladonna: it can contact smooth muscle spasm and inhibit glandular secretion. Large doses can reduce the movement and secretion of the gastrointestinal tract, the effect is generally maximum within 1-2 hours, can last for 4 hours, excreted by the kidneys; 2, atropine: oral atropine generally reaches peak effect within 1 hour, can be rapidly distributed throughout the body tissues, play a role in relaxing the smooth muscle of the gastrointestinal tract, relieve gastric spasmodic pain; 3, pethidine hydrochloride: a white, odorless crystalline powder, can be soluble in water. The body absorbed on the central nervous system, as well as cardiovascular, smooth muscle diastole has a certain effect, and clinical side effects are small, nausea, vomiting, constipation and other symptoms are generally light, the drug effect time to maintain 2-3 hours; 4, scopolamine: scopolamine belongs to the anticholinergic, has a significant relaxation of smooth muscle, release the role of vascular spasm. Generally, symptoms such as dry mouth, red face and mild pupil dilatation may occur, which may disappear after a period of time. When used in combination with omeprazole, it can reduce the side effects of omeprazole and increase the protection of gastric mucosa to promote patients’ recovery; 5. Omeprazole: It mainly acts on gastric mucosal wall cells and reduces the activity of some enzymes in the wall cells to achieve the purpose of inhibiting gastric acid secretion and protecting gastric mucosa. However, side effects such as headache, diarrhea, constipation and nausea may occur after taking the drug. In addition to overeating, bad dietary stimuli such as spicy and cold, and smoking, diseases of the gastrointestinal tract such as ulcers, gastritis, bile reflux and other diseases can also cause gastric cramps. Therefore, patients need to seek medical attention in a timely manner and use medication under the guidance of a doctor after clarifying the condition.