Midnight vomiting and waking up uncomfortable are usually caused by cold, improper diet, drug stimulation, stomach diseases, and psychological factors, as follows: 1. Cold: leads to intestinal spasm, which in turn leads to midnight vomiting and waking up uncomfortable. This situation can be used warm towels or hot water bags hot compresses abdomen, to relieve the symptoms of spasm, but also under the guidance of doctors can take domperidone, ranitidine, magnesium aluminum carbonate and other drugs for treatment, usually should pay attention to abdominal warmth, avoid cold; 2, improper diet: eating cold or stimulating food, drinking alcohol, etc. can lead to gastrointestinal dysfunction, and then such symptoms. In life, attention should be paid to adjusting dietary habits, avoiding stimulating food, it is advisable to eat a light, easy-to-digest diet, and eat more fresh fruits and vegetables. If the symptoms are severe, you can take drugs that inhibit stomach acid, such as omeprazole, under the guidance of a doctor; 3. Drug stimulation: drugs such as phenobarbital and aspirin can damage the gastric mucosa and cause the symptoms of vomiting in the middle of the night. Usually the symptoms can be relieved after stopping the drug, if the symptoms are not relieved after stopping the drug, you can go to the hospital to investigate the cause; 4, stomach diseases: such as gastritis, acute enteritis, etc. can lead to vomiting in the middle of the night, uncomfortable wake up. At this time should be symptomatic treatment, if it is caused by gastritis, can follow medical advice to take domperidone tablets, amoxicillin and other drugs for treatment. If it is caused by acute enteritis, you should pay attention to a light diet and take Flavopiridol as prescribed by the doctor for treatment; 5, psychological factors: emotional excitement, depression, tension, depression, etc. can lead to the occurrence of such phenomena, patients should pay attention to the regulation of emotions, maintain a positive and optimistic attitude, if necessary, psychological guidance, or go to the hospital specialist clinic for psychological treatment or take antidepressant drugs for treatment; 6. Early pregnancy reaction: If a woman of childbearing age who has sex has symptoms of wanting to vomit and feeling uncomfortable at night, it cannot be ruled out that it is caused by early pregnancy reaction, and it is recommended that a urine pregnancy or blood pregnancy test be performed to clarify whether she is pregnant.