The lipid-lowering drug Atorvastatin can be taken at any time of the day, starting with a small dose, followed by a gradual increase in dosage according to the condition, and regular rechecks of liver function and creatine kinase. The main effect of atorvastatin is to inhibit cholesterol synthesis rate-limiting enzyme and reduce cholesterol synthesis, and also up-regulate the cell surface LDL receptor of various tissues in the body such as liver and artery wall, accelerate the decomposition of LDL catabolism and reduce the level of LDL in the blood. Oral atorvastatin should be started at a small dose of 10mg once daily as prescribed by your doctor, and the dosage adjusted every 4 weeks according to the lipid level, with a maximum dose of 80mg. it can be taken at any time of the day and is not affected by meal intake. Side effects such as rhabdomyolysis, myopathy and hepatic impairment may occur with oral administration of atorvastatin, the magnitude of which is mostly related to the dose of the medication. Regular review of liver function and creatine kinase should be conducted. If abnormal elevation of liver function and creatine kinase is detected, prompt medical consultation should be conducted, and targeted choices of discontinuing or adjusting the dosage of the medication should be made.