How to deal with blisters on the soles of the feet should be decided according to the specific causes, blisters on the soles of the feet may be related to tinea pedis, foot eczema, feet long time friction, etc., you can use medication under the guidance of the doctor. 1. Tinea pedis: is caused by fungal infection, local blisters, erythema, itching and other symptoms, you can use ketoconazole cream, bifonazole cream, cyclopyrrolidine cream and other treatments, at the same time, need to keep feet clean and dry, wear breathable shoes as well as socks, sweating should be diligent to change and wash. 2. Foot eczema: can cause localized blisters, and itching obviously, you can use saline, boric acid powder and other wet compresses on the affected area, external anti-inflammatory creams to relieve itching, such as mometasone furoate cream, butylphenidate cream and so on. 3. foot long time friction: can also cause blisters, smaller blisters can wait for its self-absorption, daily can be rubbed with povidone iodine disinfection, if the blisters are large, should be used with the help of the doctor’s sterile syringe to extract the blisters, and can be externally used fusidic acid cream, and finally wrapped with gauze. Blisters on the soles of the feet are recommended to go to the hospital in a timely manner, to clarify the cause of the disease, and follow the doctor’s instructions for treatment, do not use their own medication to deal with.