Lung adenocarcinoma in middle or late stage without gene mutation means that patients in this stage have no mutation after genetic testing and are recommended to have active treatment. For some patients with lung adenocarcinoma in middle or late stage, no known gene mutation is detected after genetic testing, which is called lung adenocarcinoma in middle or late stage without gene mutation. For such patients, they should be alerted to the fact that it is caused by long-term smoking, environmental pollution, poor nutritional status or chronic lung diseases such as chronic bronchitis and tuberculosis themselves. For patients with lung adenocarcinoma in the middle or late stage, since the cancer cells have further metastasized to the mediastinum or extrapulmonary lymph nodes, the patients can cooperate with the doctor to undergo lobectomy plus systematic mediastinal lymph node dissection for treatment. It can also be combined with other treatments such as radiation therapy, chemotherapy and immunotherapy to prevent further aggravation of the disease. It is recommended that people with middle and late stage of lung adenocarcinoma actively cooperate with doctors to improve the survival rate. During the treatment, they should keep themselves happy physically and mentally and communicate with others more often. Pay attention to develop good living habits and ensure balanced intake of nutrients.