Tibolone is not usually taken when you have carotid plaque. Tibolone is a sex hormone and regulator of the reproductive system, and is mainly used for menopausal syndromes such as hot flashes and sweating caused by women after menopause. Carotid artery plaque may be complicated by thromboembolism, which may cause cerebrovascular diseases such as cerebral infarction. Usually in the contraindications of Tibolone, for thrombophlebitis, thromboembolism and other cardiovascular diseases or cerebrovascular disease is prohibited, in addition to severe hepatic, vaginal bleeding of unknown cause is also prohibited; therefore, patients with carotid plaque, usually can not take Tibolone. Secondly, the drug may cause headache, migraine, edema, dizziness, itching, nausea and other discomforts; and in the process of using the drug need to pay attention to, the drug can not be used as contraceptives, and also need to regularly review liver function, for athletes, elderly patients need to be used under the guidance of a doctor. The above drugs need to be used under the guidance of a doctor, avoid self-medication, so as not to cause adverse consequences.