There is no special treatment drug for pearly papules in the glans coronalis region. Pearly papules in the glans coronalis region are physiological papules common in adolescent and young men, which usually have no special clinical manifestations and therefore do not require special treatment. If there is a strong willingness to treat pearly papules, they can be treated with laser therapy or electric knife electrocautery, and their wounds can be treated with topical erythromycin ointment. In addition, pearly pimples need to be distinguished from condyloma acuminata as a sexually transmitted disease, which should be treated as soon as it is detected.