Patients in the acute stage of myocardial infarction need oxygen. Because in the acute stage of myocardial infarction, the occlusion of coronary arteries will lead to ischemia and hypoxia of the myocardium, resulting in necrosis of cardiomyocytes, thus affecting the systolic-diastolic function of the heart, heart failure, and induced pulmonary edema. The gas exchange function of the lungs is reduced, so more gas exchange is needed to maintain the oxygen supply of the body. For the oxygenation of patients with heart attack, high-flow oxygen can be given (except for patients with obstructive lung disease), and non-invasive ventilator-assisted ventilation is needed when necessary. In addition, it is also necessary to restore myocardial blood perfusion as soon as possible to save the dying myocardium, prevent infarction from expanding or reduce the scope of myocardial ischemia, and protect and maintain cardiac function. Heart attack patients need to follow the doctor’s advice when taking oxygen and standardize the treatment under the doctor’s guidance to avoid delaying the condition.