The main cause of diabetic foot is long-term diabetes, which leads to elevated blood glucose and microangiopathy, combined with peripheral nerve degeneration, called hyperalgesia, including nociception. Nociception is used to protect us from minor injuries, or early injuries, so that we know that there is an injury in the area and have to avoid it. After the hyperalgesia, the foot will walk on a very uneven surface, or the bottom of the foot has a very sharp object stabbing, you may not know, this kind of hyperalgesia, combined with local blood flow disorders, microvascular circulation disorders, the occurrence of the stabbing injury or pad injury, in this case, the local bacteria gathered here, the local blood circulation is poor, there is not good enough white blood cells to fight bacteria, local ulcers are prone to infection. Local ulcers can easily become infected, which can stimulate the development of diabetic foot. What is the cause of neuroarthritis? In fact, this kind of long-term diabetes may lead to the loss of unconsciousness, sensory distraction pre-sensory, there is a neurosensory called proprioception, this loss of sensation will make our feet in the inversion, valgus, these are not particularly safe state, our feet are not aware of this state, at the same time, the patient itself hyperalgesia, this kind of protection mechanism for the joints will be greatly lost, this situation This situation is particularly prone to the destruction of the joints of the foot and the occurrence of diabetic foot.