Lung adenocarcinoma in advanced stage may cause hoarseness due to the malignant tumor invading into the recurrent laryngeal nerve, which can be treated symptomatically with nebulizer to relieve local inflammation, and chemotherapy and targeted therapy can be carried out if the condition of the body permits. 1. Symptomatic treatment: metastasis of malignant tumor occurs in the late stage of lung adenocarcinoma, which will cause hoarseness or even inability to speak when invading the recurrent laryngeal nerve. Since the damage to the nerve is basically irreversible, it is recommended that patients go to regular hospitals for examination, and after clarifying the cause of metastasis or compression, they should take symptomatic treatments such as local nebulization to eliminate inflammation and expectoration to alleviate the symptoms. 2. Chemotherapy and targeted therapy: As the malignant cells have metastasized in the late stage of lung adenocarcinoma, chemotherapy can be carried out according to the doctor’s instruction. If the gene is positive, targeted therapy combined with immunotherapy can be carried out in order to prolong the survival period and improve the quality of life. Regardless of the treatment plan, patients should actively cooperate with doctors, maintain a positive mindset and enhance nutrition. Do not lose confidence and give up hope for life.