Amlodipine benzenesulfonate can be replaced with nifedipine, but you can’t change the medication privately, you need to change the medication under the guidance of a professional doctor. Amlodipine besylate and nifedipine can both be used to treat high blood pressure, these two drugs can be applied alone or in combination with other anti-hypertensive drugs. If you have been taking amlodipine benzenesulfonate for a while and your body has developed a resistance to the drug, so that your blood pressure does not return to the normal range, you can change to nifedipine under the guidance of your doctor to help control your blood pressure. However, it is not recommended to change the medication privately, so as to avoid improper control of the dosage. After replacing the drug, hypertensive patients need to observe whether the body has any adverse reactions, if the body has more obvious adverse reactions, to inform the doctor in a timely manner, so that the doctor can adjust the drug. Amlodipine benzenesulfonate may have adverse reactions such as edema, dizziness, palpitations, flushing and so on when using the drug treatment. Amlodipine is contraindicated in people who are allergic to amlodipine as well as any of the components of the product. Adverse reactions such as urticaria, hypotension, erythema of the upper and lower extremities, and fainting may occur with the use of nifedipine. Nifedipine is contraindicated in people who are allergic to nifedipine as well as other components of the product, unstable angina, pregnant women, and patients taking rifampicin.