Pain at the joint between the palm and the wrist may be caused by tenosynovitis, wrist sprain, osteoarthritis, rheumatoid arthritis, joint trauma, septic arthritis. 1. Tenosynovitis: If the pain at the joint between the palm and the wrist is on the dorsal side of the wrist, it may be stenosing tenosynovitis of the radial tuberosity, which is due to frequent flexion and extension of the wrist or exertion, such as holding a child too much can occur in this area of pain, and some of them can be felt locally in the hard knots. 2. Wrist sprain: If you sprain your wrist while working, you can also experience pain in the joint between the palm of the hand and the wrist, minor patients will have swelling and pain, and if there is a fracture, there will be localized bruising, and joint activity is obviously limited, and X-ray film can be taken to confirm the diagnosis. 3. Osteoarthritis: joint hyperplasia and degeneration, cartilage wear and tear caused by osteoarthritis of the wrist joints, pain in the joints between the palm and the wrist, and restriction of activities. 4. Rheumatoid arthritis: symmetrical swelling of joints, pain, and limitation of movement, which can be clearly diagnosed by rheumatology tests. 5. Joint trauma: joint ligament injury or fracture can appear in the palm and wrist joint pain, localized pressure pain, activity is limited. For example, Coley’s fracture is the pain in the joint between the palm and wrist. 6. Septic arthritis: joint infection causes redness, pain, swelling and limited movement. If the pain at the joint between the palm and the wrist is not alleviated by rest, it is recommended to go to the orthopedic department of the hospital.