Aging is a symptom of Hutchinson-Gilford Syndrome, also known as childhood progeria, a genetic disease first reported by Hutchinson in 1886. Progeria patients’ body aging process is 5 to 10 times faster than normal, the patient looks like an old man, and the organs also decline quickly, resulting in a decline in physiological functions. Signs include thinness, hair loss and late teething. Children with this rare disease can look as if they are in their 60s or 70s, even though they are only 16 years old. Most of them die from diseases of aging, such as cardiovascular disease, for which there is no effective treatment, but only medication. Although the disease is a congenital disorder, it is not certain whether it is autosomal recessive or dominant. The disease is a syndrome characterized by delayed development and progressive age-related degenerative changes that occur in infancy. The following diseases are also causes of ageing appearance: 1. Malnutrition Malnutrition is a term used to describe a health condition caused by an inadequate or insufficient diet. It usually refers to nutritional deficiencies caused by inadequate intake, malabsorption or excessive loss of nutrients, but may also include overnutrition caused by overeating or excessive intake of specific nutrients. Individuals will become malnourished if they do not consume a healthy diet consisting of the appropriate quantity, type or quality of nutrients over time. Chronic malnutrition may lead to death by starvation. 2, pediatric progeria Progeria (progeria) is a rare metabolic abnormalities, developmental disorders and dwarf state, accompanied by bones, teeth, fingernails, hair and fat and other developmental deficiencies, to childhood performance of the elderly look and arteriosclerosis as its characteristics. It was first reported by Hutchinson-Gilford (1886), so it is also known as Hutchinson-Gilford progeria syndrome. 3, nutritional and metabolic disorders The exogenous substances required by organisms to maintain normal life activities and to ensure growth and reproduction are called nutritional elements, consisting of water, minerals, carbohydrates (sugar), fats, proteins and vitamins and other six categories. Among them, water and mineral salts are inorganic substances, while fats, proteins and vitamins are organic substances. Mineral salts, in addition to more macronutrients, contain very little, but are also involved in many vital activities of the body called trace elements. These nutrients are introduced into the body through the act of eating. The normal eating behavior is controlled by many neurological, endocrine and other behavioral levels of life activities, among which the hypothalamus plays a very important role. However, in human society, eating behavior is also limited by culture, family, personal experience, personal economic conditions, and market availability. The contents of food are absorbed through the gastrointestinal tract. Most of the nutrients with large molecular weight are first converted into soluble unit nutrients with small molecular weight in the digestive tract and then absorbed by the epithelial cells of the intestine. The absorption of many nutrients requires binding to transporter proteins, whose activity is often influenced by the concentration of the substance in the body and the relevant hormones involved in its metabolism. Absorbed nutrients can be delivered to various organs and tissues for utilization, while many other nutrients can be stored in the body, especially energy substances, which can be released to the circulation for utilization when needed by the body.