Forefoot pain is not usually an early sign of cancer and may be associated with conditions such as tenosynovitis, overwork, flatfoot, and peripheral neuropathy. 1. Tenosynovitis: Tenosynovitis is caused by too much activity in the affected area. The affected area shows a lump, walking too much will aggravate the condition, this situation should be more rest, you can also appropriate massage to relieve. 2. Overwork can also cause pain in the front of the foot, if this is the cause, more rest will be better. 3. Flatfoot syndrome: this is caused by congenital factors, the patient walks a lot will also cause pain in the ball of the foot. 4. Peripheral neuropathy: for example, lumbar spondylosis compressing the nerves, neuritis, etc. may cause forefoot pain. In order to exclude cancer, patients with forefoot pain need to do relevant examinations, such as X-ray examination, tumor marker examination and foot examination. People with forefoot pain who suspect cancer should consult a doctor in time, do not blindly use medication, pay attention to rest, and standardize the treatment according to the condition under the guidance of the physician’s interview.