The bumps that you feel when you use medication outside the vagina may be related to the presence of folliculitis and warts on the vulva. 1. folliculitis: women in the vagina when the topical application of pimples, may be the vulva local hair follicle inflammation, this kind of disease is often manifested in the local hard lump, red and swollen, and accompanied by pain, usually due to poor personal hygiene, bacterial infections caused by. 2. acromegaly: the pimples can also be caused by the presence of acromegaly on the vulva, the disease is manifested as flesh-colored, granular elevation, will make the local itching, pain symptoms, and has a strong contagious.