Acute plasmacytoid otitis media belongs to acute secretory otitis media, and in the acute stage, it needs to be treated by medication (cefuroxime, etc.) and surgery. 1. Drug treatment: at this time, we need to actively control the infection, you can take oral cefixime, cefuroxime, erythromycin and other antibiotics to treat, if necessary, can be used for a short period of time to control the inflammatory response of prednisone, dexamethasone and other glucocorticosteroids. 2. Surgery: If there is a lot of fluid, the fluid can be extracted through tympanocentesis if necessary. 3. Other treatments: Medications such as budesonide nasal spray and furosemide nasal drops are needed to relieve the inflammation of the nasal cavity and nasopharynx. In addition, microwave and laser treatment can be used to help the inflammation to be absorbed. It is recommended that patients actively consult the doctor, strictly follow the doctor’s instructions for standardized medication and treatment, and not blindly self-medication.