Kidney bad can take olanzapine, olanzapine is mainly metabolized by the liver. However, the application of olanzapine in patients with renal impairment should still start at a low dose, for example, 5mg daily. Consult your doctor for specific details. Olanzapine is used for the treatment of schizophrenia, schizoaffective disorder and bipolar disorder manic episodes. In patients who are effectively treated with olanzapine, consolidation therapy can effectively promote the improvement of clinical symptoms and prevent relapse of the disease. When olanzapine is used clinically, common adverse effects include weight gain, elevated triglyceride levels, increased appetite, sedation, and elevated hepatic aminotransferases. Olanzapine should be used with caution in patients with liver disease or containing risk factors that would exacerbate hepatotoxicity. Use in patients with renal impairment is generally not restricted. Olanzapine is contraindicated in patients with known hypersensitivity to any of the components of the product and in patients with narrow-angle glaucoma. The use of olanzapine must be in accordance with medical advice and must not be self-administered.