Lung nodules that have remained unchanged for 2 years and suddenly become larger in 6 months may be malignant and require non-surgical biopsy and/or surgical resection, and postoperative radiotherapy, etc., which should be carried out in accordance with the doctor’s instructions. Lung nodules may be malignant if any of the following conditions occur during the follow-up process, such as short-term enlargement of the lung nodule, increase of the solid component or the original solid component in the lung nodule, and malignant tendency of the nodule morphology. 1. Non-surgical biopsy: mainly refers to the biopsy of pathological tissues by puncture, which can be done under the guidance of ultrasound or CT, but there are risks of puncture, such as hemorrhage, pneumothorax, hemothorax, etc. If conditions permit, PET-CT examination can also be considered to identify benign and malignant. If conditions permit, PET-CT examination can also be considered to identify the benign or malignant condition. 2. Surgical resection: Before surgery, patients should be evaluated whether they can tolerate surgery, whether they have metastasis and whether they have indications for surgery. If there is no contraindication, lung nodule resection can be performed under general anesthesia, and pathology can be sent during the operation, so that the doctor can decide whether to expand the scope of the surgery according to the pathological results. 3. Radiotherapy: some patients have high degree of malignancy or metastasis or lymph node invasion in the later stage of the postoperative period, and this part of the patients need to be further treated according to their conditions and the doctor’s formulation of radiotherapy program. Therefore, if any of the above changes are found in the follow-up process, it indicates that there is a possibility of malignant changes, and it is recommended to consult the doctor in time, and the doctor will formulate an appropriate treatment plan and follow the doctor’s instructions.