Nodules in the meat of the second joint of the little finger may be related to hyperplasia and hypertrophy of the stratum corneum, foreign body cysts, folliculitis, tendon sheath cysts and rheumatic diseases. 1. Hyperplasia of the stratum corneum: If the second joint of the little finger is often squeezed and abraded, in the long run, it can cause local hyperplasia of the stratum corneum of the skin, resulting in hard nodules, which may be accompanied by slight pressure pain. 2. Foreign body cysts: if the second section of the little finger when there is a foreign body stab wound, causing local foreign body residue, local parcel so that the second section of the little finger within the hard knot. 3. Folliculitis: mostly related to the unclean skin in the second part of the little finger, resulting in local follicular canal blockage, which further causes localized inflammation and formation of hard nodules. 4. Tendon sheath cysts: long-term strain on the second joint of the little finger can cause extravasation of fluid in the joint and tendon sheath cysts, which can be manifested as nodules in the meat of the second joint of the little finger. 5. Rheumatic diseases: such as gout caused by calcium deposition of local gouty nodules, lesions occur in the second joint of the thumb, can cause local nodules, accompanied by swelling and pain. If nodules appear in the second thumb and are difficult to disappear, it is recommended to go to the hospital in time to find out the cause of the nodules, and then actively treat them, so as not to delay the condition.