Patients with gastroenteritis are better off without ibuprofen, and non-steroidal drugs, including ibuprofen, are avoided as much as possible, such as aspirin, indomethacin, nefoxan, diclofenac sodium, acetaminophen, etc. These drugs have significant antipyretic, analgesic, anti-inflammatory and anti-rheumatic effects. However, the most common side effects of these drugs are the induction and aggravation of acute hemorrhagic gastritis and peptic ulcers. The intestinal mucosa itself may be congested, edematous, eroded, and rebleeding in patients with gastroenteritis, and oral administration of NSAIDs can aggravate the damage to the gastrointestinal mucosa. Some patients with gastroenteritis who develop fever may be given physical cooling, ice pillows, alcohol baths, etc., and oral Xiao Chai Hu granules as well as antipyretic drugs to relieve symptoms. If the fever does not subside, indomethacin suppositories can be given to reduce the direct oral gastrointestinal irritation, and the patient is advised to eat a light, easily digestible, warm and soft diet with few and many meals.