Blackheads refer to open pimples, a mild type of acne. When a patient develops blackheads, he or she can be treated with medications such as retinoic acid ointment, azelaic acid ointment, and benzoyl peroxide gel as prescribed by the doctor in order to improve the symptoms. 1. Vitamin A acid ointment: Adapalene ointment belongs to the vitamin A acid class of drugs, which has the effect of improving the keratinization of follicle sebaceous gland ducts, dissolving pimples, anti-inflammatory, preventing and improving the post-inflammatory hyperpigmentation of acne, which can improve the symptoms of blackheads, and the same kind of drugs are also available as isotretinoin gel, tazarotene gel, and so on. 2. Azelaic acid ointment: Azelaic acid ointment can reduce the bacteria on the skin surface, in the hair follicles and sebaceous glands, and it has a dissolving effect on blackheads and acne, and this drug can be used as a second-line therapeutic drug for blackhead treatment. 3. Benzoyl peroxide gel: Benzoyl peroxide gel is a keratolytic agent, which has the effect of killing Propionibacterium acnes, anti-inflammatory and mildly dissolving pimples and blackheads, and it can also be used in conjunction with retinoids. When patients with blackheads are combined with bacterial infections, antibiotic preparations such as mupirocin ointment and fusidic acid cream can be used in conjunction. It is recommended that patients strictly follow the doctor’s instructions for medication, do not abuse drugs privately, so as not to affect the therapeutic effect, in the life of the patient should pay attention to personal hygiene, to keep the face clean, dry, and follow the doctor’s instructions for regular follow-up.