Whether female splenomegaly is serious or not needs to be analyzed according to the degree of splenomegaly, clinical symptoms, personal physical condition and so on. Mildly enlarged spleen is common in acute and chronic viral hepatitis, typhoid fever, infective endocarditis, sepsis, etc. Moderately enlarged spleen can be seen in cirrhosis of the liver, sequelae of malaria, chronic lymphocytic leukemia, lymphoma, etc. Significantly enlarged spleen can be seen in black fever, myelofibrosis, etc. In some cases, though the spleen is mildly enlarged, but the disease itself is serious enough to require timely treatment measures. When you find an enlarged spleen, you should go to a professional hospital immediately to identify the cause of the enlarged spleen and take appropriate treatment under the guidance of a professional doctor in order to maximize the quality of life.