High carbon dioxide binding capacity may be a sign of acute gastroenteritis, pyloric obstruction, pulmonary heart disease and other diseases. 1. Acute gastroenteritis: when the gastrointestinal tract is attacked by pathogenic microorganisms due to unclean diet, it is easy to cause acute gastroenteritis, which may be manifested as vomiting and diarrhea, which may lead to metabolic alkalosis and high CO2 binding capacity. 2. Pyloric obstruction: the formation of pyloric obstruction may be related to factors such as peptic ulcer and malignant tumors. When the condition is severe, it may cause hypochlorhydria and hypokalemic alkalosis, which may also lead to high carbon dioxide binding capacity. 3. Chronic Pulmonary Heart Disease: Chronic pulmonary heart disease can lead to dyspnea after activity, and cardiopulmonary insufficiency and other organ involvement in the long run may also lead to high CO2 binding capacity. High CO2 binding capacity may also be caused by other reasons, and you should go to the hospital in time for further examination to clarify the specific disease and prevent the condition from worsening.