Penile edema is mostly caused by inflammatory infections, circumcision, phimosis, etc. It can be improved by taking anti-infective medication and surgical treatment. 1. Inflammatory infections caused by penile edema: can be treated by using anti-infective drugs, commonly used oral anti-infective drugs such as cefixime, roxithromycin, amoxicillin, etc., topical anti-infective drugs such as erythromycin ointment, which can effectively improve the symptoms of penile edema. 2. The long foreskin and the penis edema caused by the foreskin: can be treated by surgery, through the circumcision to remove the long foreskin, can effectively relieve the symptoms of penile edema. These medications have different degrees of adverse reactions, when using these drugs must be strictly in accordance with the doctor’s instructions under the guidance of a doctor.