Cryptococcus neoformans found in cerebrospinal fluid may be a subacute, chronic inflammatory disease caused by meningitis and encephalitis. Cryptococcus neoformans is a fungus that can be transmitted through the respiratory tract and mainly attacks the central nervous system. When the human body’s immunity is low, it is easy to be infected by Cryptococcus neoformans and cause central nervous system cryptococcosis, which may be found in the cerebrospinal fluid of the human body, and infringes on the brain or the meninges to cause cryptococcal meningitis, encephalitis, etc. The patient may have fever, encephalitis, and may have a fever that may be caused by the fungus. It may lead to fever, headache, nausea and vomiting, impaired consciousness, hearing impairment and other symptoms. Prompt antifungal treatment under doctor’s supervision is needed, such as injectable amphotericin B, flucytosine tablets and other drugs. Patients with novel cryptococcus found in the cerebrospinal fluid should be treated with appropriate medications under the guidance of a doctor, and should not take them without authorization.