Metoprolol is the most commonly used beta-blocker in clinical practice. If a beta-blocker needs to be discontinued, it should not be stopped abruptly, but needs to be stopped slowly. If abruptly discontinued, it will cause the heart rate to rebound, significantly increase myocardial oxygen consumption, and even induce angina pectoris in patients, so beta-blockers should be discontinued slowly. In the case of metoprolol, it is important to maintain the duration of the discontinuation process for more than 2 weeks, halving the dose every 2-3 days and finally reducing it to the minimum dose for 4 consecutive days, and only after 4 days can the drug be stopped cautiously. The patient’s heart rate should be closely monitored during discontinuation and a discontinuation plan should be developed under the guidance of the physician. Most patients with coronary artery disease may require long-term oral metoprolol therapy, so do not discontinue the drug on your own.