Gurgling after quadruple therapy may be related to adverse drug reaction and improper diet, which can be relieved by stopping the medication and adjusting the diet. 1. Drug reaction: quadruple therapy is a therapeutic treatment containing two antibiotics, a proton pump inhibitor and a bismuth agent for the eradication of Helicobacter pylori. The above situation may be a digestive reaction caused by gastrointestinal dysfunction due to antibiotics, and the symptoms will disappear gradually after stopping the medication after taking a full course of treatment. 2. Improper diet: After the quadruple therapy, if you take too cold, too spicy, too greasy food or inhale cold air, it may cause intestinal contraction, resulting in intestinal tinnitus symptoms. It is necessary to adjust the dietary pattern, regular and quantitative, avoid eating cold, spicy and stimulating food. If there is any discomfort such as tinnitus after the quadruple therapy, it is recommended to go to the hospital in time, clarify the cause of the disease and adjust the medication under the guidance of a professional physician.