When signs such as lobular signs and marginal burrs are found in lung nodules during examination, malignant lesions are highly suspected and should be taken seriously. If the nodule is benign, it is generally not serious and regular follow-up is sufficient. In the case of pulmonary nodules, the presence or absence of lobar sign, burr sign, vacuolar sign, and regularity of the shape of the nodule should be taken into account in the preliminary analysis of its benign or malignant nature. If the nodule is large and the above conditions exist at the same time, the tumor-related examination should be further improved, and depending on the location, bronchoscopy or thoracocentesis biopsy should be chosen to confirm the diagnosis. If the lung nodule is determined to be a malignant tumor, corresponding therapeutic measures should be taken according to different pathological types and stages. If the nodules have regular morphology, clear peripheral boundaries, uniform internal texture, no ground glass-like manifestations as well as no signs such as lobulation and burrs, the possibility of benign is considered greater, and regular follow-up examinations in the hospital can be performed. If patients find small lung nodules, they should actively consult the doctor for a clear diagnosis and follow the doctor’s instructions for reasonable treatment.