Low white blood cells and neutrophils are less likely to be leukemia, which may be related to infections, blood system diseases such as aplastic anemia, hemophagocytic syndrome, etc. However, it is not excluded that certain leukemias, which may have low white blood cells and neutrophils, may be manifested. 1. Infections: Gram-negative bacilli such as typhoid fever, paratyphoid infection, viral infections such as influenza virus, hepatitis virus, etc. can lead to low white blood cells and neutrophils. After actively controlling the infection, the white blood cell and neutrophil counts will gradually return to normal. 2. Hematologic diseases: patients with aplastic anemia, hemophagocytic syndrome and other diseases may also have low white blood cell and neutrophil counts. These patients usually need to complete bone marrow aspiration + biopsy to clarify the diagnosis, and under the guidance of doctors to correct anemia, immunosuppression (cyclosporine), hematopoietic stem cell transplantation and other treatments. 3. In addition, patients with long-term exposure to ionizing radiation and some autoimmune diseases such as systemic lupus erythematosus and desiccation syndrome may also have low white blood cells and neutrophils. However, certain hypoproliferative leukemias may also have low white blood cells and neutrophils, and require differential diagnosis under the guidance of a physician. Warm reminder: low white blood cells and neutrophils is less likely to be leukemia, the patient should consult the doctor in a timely manner, if necessary, to further improve the relevant laboratory tests, under the guidance of the doctor’s treatment.