Nowadays, the treatment of gastric cancer includes surgery, chemotherapy, radiotherapy, biological therapy and traditional Chinese medicine, which is summarized as multidisciplinary standardized, individualized and comprehensive treatment. Among them, surgery is the main and primary treatment method, especially for early gastric cancer, surgery is the only way to cure it. For early to mid-stage gastric cancer, surgery is recommended for those who can undergo surgery and meet the conditions for surgery; for advanced gastric cancer, unless there are extensive metastases, radical surgery should be pursued. For those who cannot be removed by radical surgery, some palliative surgery can be done, which are very important. Postoperative adjuvant chemotherapy is the most commonly used comprehensive treatment for gastric cancer. Cell kinetic theory research shows that various types of anti-cancer drugs have different effects in each phase of proliferating cells, and the same group of proliferating cells are not in the same proliferation cycle, so the simultaneous application of different anti-cancer drugs can have synergistic effects and enhance the effect, and at the same time reduce the emergence of drug resistance of cancer cells. Therefore, postoperative chemotherapy should be combined with chemotherapy. Postoperative adjuvant chemotherapy should be administered as early as possible, usually within 2 weeks after surgery. Intraperitoneal infusion chemotherapy is one of the most important methods in the treatment of gastric cancer, because the surgical operation may cause intraperitoneal implantation of cancer cells. Intraperitoneal infusion chemotherapy can reduce intraperitoneal implantation, and at the same time, chemotherapeutic drugs are absorbed and returned to liver with portal blood, which can contain liver metastasis of gastric cancer. Radiotherapy is not routinely used after gastric cancer surgery. Because most of gastric cancer is adenocarcinoma, which is not sensitive to radiation, mucinous adenocarcinoma and indolent cell carcinoma are not effective in radiotherapy, and hepatopancreas is highly sensitive to radiation, which can easily cause radiation damage. Since gastric cancer metastasizes earlier, the radiation field cannot include all its metastases, so postoperative radiotherapy for gastric cancer can do more harm than good. However, if the tumor cannot be completely removed due to anatomical conditions, postoperative radiotherapy can be considered after the cancer residuals are marked intraoperatively and its histological type is confirmed by pathology after surgery. Immunotherapy, molecular targeted therapy and traditional Chinese medicine are the directions of contemporary anti-tumor drugs, which mainly regulate the body’s defense function and improve the body’s anti-tumor ability, and are important parts of comprehensive treatment.