Most of the chronic osteomyelitis can be cured, and it needs effective, active, standardized and rationalized treatment to achieve the purpose of cure. Chronic osteomyelitis is a chronic infectious inflammatory disease that occurs in the periosteum, bone marrow, and bone mass, and the symptoms are usually confined to the local area, and may show phenomena such as tissue sclerosis, necrosis, fistulae, and pus, etc. It can be cured after effective and active treatment. The treatment of chronic osteomyelitis is mainly based on thorough debridement and drainage. The main purpose of debridement is to remove diseased tissues and sinus tracts, and if accompanied by pus, it is necessary to cooperate with drainage surgery. During treatment, anti-infective drugs such as cefuroxime and amoxicillin should be taken as prescribed by the doctor to improve the therapeutic effect. Most chronic osteomyelitis can be cured through active treatment, it is recommended that patients go to the hospital in a timely manner, under the guidance of the doctor to take standardized treatment, even if the disease can not be completely cured, but also through the treatment to control the development of the disease.