Multiple small lymph nodes in right lower abdomen may be caused by appendicitis, ascending colitis, ascending colon cancer and other diseases. 1. Appendicitis: Inflammation stimulates the mesentery, which will lead to inflammatory hyperplasia of mesenteric lymph nodes, resulting in lymph node enlargement, causing the manifestation of multiple small lymph nodes in the right lower abdomen. 2. Ascending colitis: it is also due to the fact that there are a lot of lymph nodes around the large blood vessels in the mesentery of the right lower abdomen of the human body, and the inflammatory stimulation will make the lymph nodes hyperplasia and enlargement, which will result in the occurrence of multiple small lymph nodes in the right lower abdomen. 3. Ascending colon cancer: cancer cells in patients with ascending colon cancer may metastasize, and the metastasis to mesentery will cause bacterial lymph nodes to enlarge and swell, which will lead to multiple small lymph nodes in the right lower abdomen. Multiple small lymph nodes in the right lower abdomen may also be seen in inflammation of the end of ileum, digestive tract or pelvic tumor, pelvic inflammation, adnexitis and other diseases, in addition, respiratory infections in children may also appear with enlarged lymph nodes in the area. If symptoms of multiple small lymph nodes in the lower right abdomen occur, prompt medical attention is needed.