Patients with advanced stage of liver cancer are physically weak and need to be regulated by traditional Chinese medicine. The specific formula should be based on the patient’s physique for diagnosis and treatment: I. Liver depression and spleen deficiency syndrome, manifesting as stuffy and uncomfortable epigastrium, lethargy, fatigue, abdominal distension, poor appetite, dry mouth, dislike of drinking, fat tongue and white tongue coating, the recommended formula is Easy Dispenser Combined with Sijunzi Soup plus and minus; II. Liver and gallbladder dampness-heat syndrome, manifesting as heaviness of the head, drowsiness, yellow staining of the body and eyes, upset, irritable, fever, thirst, red tongue, yellowish and greasy tongue, the recommended formula is Yin Chen Artemisia Soup plus and minus; III. Liver-heat and blood stasis, manifesting as hard epigastric mass, pain at the top of the abdomen and refusing to be pressed, irritable heat, dry mouth, dry lips, dry and knotty stools, red tongue texture, white and thick tongue coating, the recommended formula is Gentian Diarrheal Liver Soup combined with Lower Bruised Blood Soup with additions and subtractions. 4. Dampness and sleepiness in spleen deficiency, manifesting as abdominal enlargement, distension and fullness, fatigue, malaise, heaviness, dullness, heaviness of the limbs, swelling of the feet, scanty urination, wetness of the tongue with tooth marks and thick and greasy moss, the recommended formula is Sijunzi Tang combined with Wu Pi Drink with addition and subtraction; v. Yin deficiency of liver and kidney, manifesting as dropsy, swelling of limbs, purpura of limbs, shortness of breath, wheezing, red lips, dry mouth, reddish-red tongue, glossy tongue, and no moss, and the recommended formula is Consistent Decoction with Flavor. In conclusion, patients with advanced stage of liver cancer should be treated with traditional Chinese medicine.