1. What are the benefits of surgical resection of brain metastases? ①Total removal of metastases can rapidly relieve the symptoms of intracranial hypertension, eliminate the stimulation of metastases on surrounding brain tissues, and significantly improve the quality of patients’ survival. ②Tumor tissues can be obtained to clarify the pathological diagnosis. ③Surgery can achieve local cure by removing the whole tumor and prolong the survival period of patients. 2. Which patients with brain metastases are suitable for craniotomy? Which brain metastases are not suitable for surgical treatment? ①Patients with single brain tumor, suitable location and easy to resect, especially patients with severe tumor or its edema occupying effect, or patients with hydrocephalus. ②Patients with large size of brain metastases and/or edema, intracranial pressure loss, tumor stroke, etc. on the verge of brain herniation and life-threatening should undergo emergency surgery. ③The number of multiple brain metastases ≤3, and those who can be completely resected by surgery and can obtain satisfactory results similar to those of single brain metastases should be considered for surgery. ④When more than 3 brain metastases present with life-threatening tumor stroke and obstructive hydrocephalus, craniotomy should be performed to remove the lesion and decompress it. ⑤ Surgery is preferred for tumors with maximum diameter greater than 3 cm; radiotherapy or chemotherapy is preferred for tumors with maximum diameter less than 5 mm, especially those located in deep brain (thalamus, brainstem, etc.); if the maximum diameter of tumor is between 1 cm and 3 cm, surgery or other treatments are preferred according to the comprehensive assessment of systemic condition and surgical risk. (6) Tumor site: In principle, surgery is not preferred for brain metastases located in brainstem, thalamus and basal ganglia. 3. What are the treatment methods for meningeal metastases? ①For patients with meningeal metastases, chemotherapy drugs can be injected into the ventricles of the brain regularly by implanting Ommaya reservoir sacs. Compared with sheath injection via lumbar puncture, Ommaya reservoir is safer and avoids the risk of inadvertent injection of drugs into the epidural space by sheath injection. ②Ventriculo-abdominal shunt is feasible for patients with combined traffic hydrocephalus to reduce intracranial pressure and relieve symptoms, but ventriculo-abdominal shunt may increase the chance of tumor metastasis in the abdominal cavity. 4. Can patients with recurrence of brain metastases after resection undergo surgery again? The recurrence of brain metastases can significantly improve the quality of life and survival of patients if they are still suitable for surgery after considering the number, location and general condition of the tumor.