Sequelae of nuclear jaundice can usually be avoided with prompt treatment in the early stages. Kernicterus jaundice, also known as neonatal bilirubin encephalopathy, is an acute brain injury caused by bilirubin toxicity in newborns. The main reason is that too much bilirubin is produced in the early stage of life. The liver function of the newborn is not well developed, and the excess bilirubin can not be discharged from the body through the liver. Since the blood-brain barrier is not developed in newborns, bilirubin can enter the brain to form kernel jaundice. Neonatal bilirubin encephalopathy can be treated by red and blue light and blood exchange therapy to promptly and rapidly reduce the concentration of bilirubin in the blood and prevent the progression of the disease; intravenous injection of gammaglobulin and albumin can also be used for treatment, and if cured completely, there is usually no after-effects. After the newborn suffers from kernel jaundice, parents must follow the doctor’s instructions to actively cooperate with the doctor for treatment, do not self-medication, so as not to delay the condition.