The time of using targeted drugs for liver cancer needs to be decided according to the severity of the disease and the physical quality of the patient, and the time of taking the drugs may be half a year or even long-term, and the drugs should be used according to the doctor’s prescription. Targeted drugs commonly used by liver cancer patients include Apatinib, Sorafenib, Lenvatinib, etc. Targeted drugs usually can effectively inhibit the malignant proliferation of tumor cells, reduce the tumor foci and improve the prognosis of the disease. Usually they need to be taken for more than half a year, and patients in the department need to take them for a long time. Usually, the above drugs are applied in combination with surgery, local therapeutic procedures (intervention, ablation, etc.) or chemotherapy, and some patients can also be applied with single drug. However, the drugs need to be used under the guidance of a doctor, the occurrence of adverse reactions (hypertension, proteinuria, diarrhea, loss of appetite, fatigue, and hand-foot syndrome, etc.) timely medical treatment, drug allergy is prohibited. It is recommended to go to a regular hospital to assess the condition, follow the doctor’s instructions to cooperate with the treatment, choose the appropriate treatment program, so as to avoid delaying the condition. Please strictly follow the doctor’s instructions, do not self-medication.