Physical fatigue may come from physiological factors, or it may be a manifestation of disease. If the recent work, life is more strenuous, after engaging in heavy physical labor, can appear physical fatigue, physical exertion performance, this situation timely attention to rest, adjust life, diet habits, generally can gradually recover. In addition, we should consider whether the disease is a factor, first consider whether there is anemia, you can do routine blood tests, if the hemoglobin is abnormal, consider the existence of anemia, to further clarify the cause. For female patients, it is also necessary to exclude the presence of thyroid diseases, such as hypothyroidism, where the patient may show signs of physical exertion. For middle-aged and elderly patients or patients with family history of tumor, we should pay attention to clarify whether there are other symptoms and signs, such as significant weight loss and physical exertion in a short period of time, and we should pay attention to further examination to clarify whether there are tumor-related diseases. Due to the high prevalence of tumor diseases in recent years, attention must be paid to exclude the related manifestations and then give the corresponding treatment.