Chronic glomerulonephritis has a high chance of developing into uremia, which is usually closely related to the factors such as pathology, disease control, etc., with large individual differences, and there are some patients with stable conditions who do not develop to the stage of uremia in the end. Chronic glomerulonephritis, referred to as chronic nephritis, is characterized by proteinuria, hematuria, hypertension and edema as the basic clinical manifestations, with different ways of onset, and the condition is prolonged and slowly progressing, with varying degrees of renal function impairment, and some patients will eventually develop to end-stage renal failure. Chronic glomerulonephritis can be seen in a variety of renal pathology types, mainly mesangial proliferative glomerulonephritis (including IgA and non-IgA mesangial proliferative glomerulonephritis), mesangial capillary glomerulonephritis, membranous nephropathy and focal segmental glomerulosclerosis. When the lesion progresses to the advanced stage, the kidney volume shrinks, the renal cortex thins, all pathological types can progress to varying degrees of glomerulosclerosis, renal tubular atrophy of the corresponding renal units, interstitial fibrosis, and the severe cases can eventually evolve into uremia, so the chances are greater. Chronic glomerulonephritis condition is prolonged, the lesions are slowly progressing, may eventually progress to uremia. The rate of progression varies greatly among individuals, depending on the type and severity of renal pathology, whether effective measures are taken to slow down the progression of renal function, whether appropriate treatment is given, and whether various risk factors are avoided. It is recommended that patients with chronic glomerulonephritis should consult a doctor in time and actively cooperate with the doctor for standardized treatment in order to slow down the progression of the disease.