Xiao Wang is 35 years old, never smoked, never drank alcohol, one day suddenly felt the left lower extremity swelling pain, walking difficulties, to the hospital to do an ultrasound can be dumbfounded, it turns out that Xiao Wang has a left lower extremity venous thrombosis. Fortunately, the doctor applied heparin and warfarin to Wang in time. Due to the timely treatment and regular medication, the thrombosis actually disappeared after 3 months of review. Xiao Wang was very strange, he never smoked or drank alcohol, so why did he suddenly get thrombosis? He did not have high blood pressure, diabetes, or high blood lipids, and his family did not have a history of thrombosis, so after thinking about it, Wang stopped taking warfarin. One day, 1 month later, Xiao Wang suddenly felt tightness in his chest and could not catch his breath. Xiao Wang immediately came to the hospital’s emergency department, and when he arrived at the emergency department, Xiao Wang was immediately pushed to the emergency care unit. It turned out that Wang had a venous thrombosis of the right lower extremity, and had a pulmonary embolism, and was in respiratory failure. Due to the timely consultation, the doctor gave Xiaowang timely thrombolytic treatment. After active treatment, Wang was finally released from life-threatening conditions. What is the reason for Xiao Wang’s repeated thrombosis? Doctors from the Department of Rheumatology and Immunology have revealed the real culprit – antiphospholipid syndrome. Antiphospholipid syndrome is a syndrome of recurrent thrombosis, miscarriage and thrombocytopenia accompanied by positive phospholipid antibodies. Antiphospholipid antibodies are a group of antibodies that react with a variety of antigenic substances containing phospholipid structures, including lupus anticoagulant and anticardiolipin antibodies. Blood clots can occur in arteries or veins. Among the thromboses, recurrent deep vein thrombosis is more common, including renal, retinal and inferior vena cava. Among arterial thrombosis, stroke, myocardial infarction, pulmonary and renal infarction are common. Patients may present with symptoms such as unfavorable limb movement, chest pain, and wheezing. In addition to thrombosis, manifestations such as thrombocytopenia, psychiatric symptoms, reticular cyanosis of the skin, skin ulcers, and in some female patients, recurrent miscarriages can occur. The treatment of antiphospholipid syndrome with thrombosis as the main manifestation is mainly anticoagulation. In the acute phase of thrombosis, heparin or low-molecular heparin therapy is required. Long-term treatment requires oral anticoagulants, and the most commonly used anticoagulant in clinical practice is warfarin. the target value of anticoagulation is an INR of 2.0 to 3.0. if INR > 3 the risk of bleeding increases, and INR > 5 the risk of bleeding is great. In addition to anticoagulation therapy, a drug for diagnosing immune abnormalities needs to be applied, that is hydroxychloroquine. If other manifestations such as thrombocytopenia are combined, other immunosuppressive drugs need to be added depending on the situation. Therefore, we remind you to consult the rheumatology department promptly if you have recurrent thrombosis, or thrombosis in young patients, or thrombocytopenia, skin ulcers, and other manifestations.