Rotavirus infection with a fever of 40 degrees is recommended to reduce heat treatment, prompt hospitalization and often requires rehydration. Rotavirus is an enterovirus that can cause fever, diarrhea, general weakness, and in severe cases, dehydration and convulsions. Rotavirus fever of 40 degrees need to be cooled down as soon as possible, can be taken to physical cooling and drug cooling combination. Physical cooling can generally use warm water to wipe the forehead, neck, armpits, groin, chest, palms, feet and other parts of the body to accelerate the dissipation of heat to achieve the effect of cooling. Drugs can choose acetaminophen suspension or ibuprofen suspension for antipyretic treatment. Rotavirus fever of 40 degrees is more serious, need to go to the hospital for timely examination and treatment, rotavirus infection is easy to cause diarrhea, need to pay attention to rehydration, especially in children with sunken eye sockets, crying without tears and other signs suggesting dehydration.