After colon tumor infiltrates the bladder, surgery, radiotherapy and targeted therapy can be chosen to improve the prognosis of the disease, and the treatment should be carried out under the guidance of doctors. After infiltration of colon tumor into bladder, it suggests that the disease has deteriorated, and it is difficult to completely remove the tumor lesion through surgical treatment, so it is necessary to reduce the tumor lesion, inhibit the growth of tumor cells, improve the quality of life of the patient through radiotherapy and targeted therapy, and surgical resection is given when the situation permits. Chemotherapy drugs that patients can choose include cyclophosphamide, vincristine, cisplatin, paclitaxel and so on; targeted drugs include cetuximab, panitumumab and so on. As the drug is not absolutely the most effective, need to follow the doctor’s instructions to use the drug, drug adverse reactions promptly consult a doctor, drug allergy is prohibited. If combined with vesicoconjunctival fistula, it is usually recommended to give the lesion segment resection (or colostomy or radical treatment of colorectal cancer) combined with vesicoconjunctival fistula repair (or partial cystectomy, etc.) and other surgical treatments, and postoperative need to be given according to the situation of radiotherapy or chemotherapy, to improve the patient’s prognosis and quality of life. After colon tumor infiltrates the bladder, patients are advised to keep a good mindset and actively cooperate with doctors to receive treatment.