Painful blood in stool may be caused by hemorrhoids, anal fissure, ulcerative colitis, rectal cancer, with different causes and different treatments. 1. Hemorrhoids: Hemorrhoids is a kind of disease caused by congested and enlarged veins in the anal canal or lower end of the rectum, which can lead to the symptom of blood and pain in stool, and can be treated with medicines such as tylenol suppository and hemorrhoidal ointment, and can be treated by hemorrhoidectomy. 2. anal fissure: anal fissure is a kind of fissure of the skin layer of the anal canal below the dentate line, forming small ulcers of the disease, the disease can also lead to the patient to appear in the stool blood pain symptoms, the treatment can be used to use potassium permanganate warm water sitz bath to keep the local clean, but also can be used to relieve the pain of the local lidocaine ointment, in addition can be through the fissure excision surgery for treatment. 3. Ulcerative colitis: ulcerative colitis is a kind of chronic non-specific intestinal inflammatory disease, which can also lead to the symptoms of blood and pain in stool, and can be treated with mesalazine, salazosulfapyridine, dexamethasone, azathioprine and other drugs. 4. Rectal cancer: Rectal cancer may cause blood in stool with pain, which requires surgical treatment. Generally, according to the tumor condition, low anterior rectal resection, abdominal perineal colectomy, colostomy Hartmann’s surgery and so on are performed. After surgery, radiotherapy, chemotherapy and targeted therapy are performed according to the situation. In addition to the above diseases, other diseases can also lead to the symptoms of blood in stool and pain, it is recommended to consult a doctor in time to identify the cause and ask the doctor to deal with it.