Whether the newly transplanted kidney can function normally is a concern for both doctors and patients; at the same time, the immunosuppressants commonly used after kidney transplantation can also cause damage to the kidneys, so patients should ensure regular follow-up examinations on time. Generally speaking, for patients with ideal results after transplantation, creatinine examination can reach normal level in about a week, and there are a few people whose creatinine decreases slowly until normal; and during long-term examination, there is no difference between patients’ urine protein and creatinine assessment criteria and ordinary people. If the primary disease is IGA nephropathy, crescentic glomerulonephritis and other immune factors leading to uremia, doing kidney transplantation may also cause damage to the new kidney, but this process varies from person to person. For patients who take medication on time, renal failure will not usually occur again within 1-2 years, or at least 3-5 years. However, kidney transplant drugs themselves are commonly used to treat these primary diseases (e.g. hormones, immunosuppressants, etc.) and can also play a role in inhibiting the recurrence of immune nephropathy. These patients should pay more attention to the regular testing of urine protein. If they have high urine protein, continuous creeping creatinine, or even severe edema of the extremities, it is better to clarify the cause by transplant kidney puncture. And kidney puncture usually does not cause much damage to the new kidney, the puncture needle diameter is very thin, about 1-1.5 mm, puncture 2-3 thin strips in the kidney, take out very little kidney tissue, will only leave a little wound on the body surface; if the disease is not diagnosed in time because of the fear of not doing the test, the loss to the kidney will be even greater.