A skin disease without any skin damage and predominantly pruritic is clinically diagnosed as pruritus. Pruritus is generally divided into two types: generalized and restricted.1. There are many causes of generalized pruritus, including temperature stimulation, chemical stimulation, dry skin, and hyposecretion of sebaceous glands, all of which can cause generalized pruritus. Many systemic diseases can also cause generalized pruritus, such as uremia, cholestasis, diabetes mellitus, and abnormal parathyroid function. 2, limited pruritus causes, sometimes the same as generalized pruritus, such as diabetes mellitus can cause both generalized pruritus and local pruritus. Anal itching is mostly related to pinworm disease, prostatitis, hemorrhoids. Pubic itching is mostly related to local sweating, friction, and vaginitis. If the pruritus is relatively short, you can take oral antihistamines, such as desloratadine tablets and epalatine tablets, and use menthol or glucocorticoid ointment topically. If the pruritus is prolonged, it is best to have a comprehensive internal examination to clarify the cause.