The side effects of saffron in water are not clear. Saffron in water has the effects of activating blood circulation and removing blood stasis (promoting blood circulation and eliminating blood stasis in the body), cooling the blood and detoxifying the toxin (referring to the treatment of blood-heat and toxicity). Saffron is sweet in flavor and flat in nature. It belongs to the heart and liver meridians. It has the effects of activating blood circulation, removing blood stasis, cooling blood and removing toxins, relieving depression and tranquilizing the mind. It is used in treating menstrual obstruction, postpartum stagnation, dampness-poisoned spots (warm and hot poisonous evils invading the body resulting in spots and plaques on the skin), depression and congestion, palpitation and frenzy, etc. It is also used in treating the symptoms of depression and congestion. Saffron can be used as a decoction for internal use, as a powder, or as a pill or powder. The effective dosage is limited, and it is difficult to achieve the therapeutic effect. Pregnant women should take it with caution. The use of saffron to treat diseases, should be under the guidance of a doctor to identify the evidence of medication.